EndoSphere works with nature
Using the body’s Natural Physiology to amplify Satiety
EndoMetabolic Devices
EndoSphere’s devices have been clinically proven to facilitate Excess Weight Loss (EWL) without the need for surgery or weight-loss drugs, and without the need to restrict the available capacity of the patient’s stomach.
Unique focus on Duodenum
EndoSphere’s Core Competencies include expertise on treating the Duodenum -- the upper intestinal organ widely recognized for its role as the body’s Metabolic Control Center.
Non-Invasive
EndoSphere’s therapy is incision-less, reversible, and repeatable.
Strong clinical evidence
Published human studies with significant efficacy measured by excess weight loss (EWL).
Completely new category
EndoSphere’s platform of endo-metabolic devices introduces a new paradigm for treating obesity.
Why focusing on the Duodenum is important?
EndoSphere’s devices focus on the Duodenum because that organ is widely recognized as the body’s Metabolic Control Center. When ingesta enters the Duodenum, the neurons lining the walls of the Duodenum respond to the ingest by triggering the release of appetite-suppressing and satiety-inducing hormones including CCK and GLP-1 into both the bloodstream (sending messages to the brain and managing a brain-gut feedback loop) as well as into the gastrointestinal tract (slowing digestion by signaling the pylorus and the sphincter at the end of the Duodenum to close and continued flow of ingesta).